In the 1960s, I continued the work on the secretory...

Quote by George Emil Palade about medicine, univers, research, animals, work, good, good luck

In the 1960s, I continued the work on the secretory process using in parallel or in succession two different approaches. The first relied exclusively on cell fractionation, and was developed in collaboration with Philip Siekevitz, Lewis Greene, Colvin Redman, David Sabatini and Yutaka Tashiro; it led to the characterization of the zymogen granules and to the discovery of the segregation of secretory products in the cisternal space of the endoplasmic reticulum. The second approach relied primarily on radioautography, and involved experiments on intact animals or pancreatic slices which were carried out in collaboration with Lucien Caro and especially James Jamieson. This series of investigations produced a good part of our current ideas on the synthesis and intracellular processing of proteins for export. A critical review of this line of research is presented in the Nobel Lecture.

George Emil Palade
Quote by George Emil Palade about medicine, univers, research, animals, work, good, good luck.
George Emil Palade

George Emil Palade 1912 - 2008 Romanian cell biologist

Was born on: 19 nov 1912.
Died on 08 oct 2008, at 95 years old.
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