De la Motte was born and died in Paris. In 1693 his comedy, Les Originaux (Les originaux, ou, l'Italien), was a complete failure, and so depressed the author that he contemplated joining the Trappists. Four years later he began writing texts for operas and ballets, e.g. L'Europe galante (1697), and tragedies, one of which, Inès de Castro (1723), was an immense success at the Theâtre Français. He was a champion of the moderns in the revived controversy of the ancients and moderns. His Fables nouvelles (1719) was regarded as a modernist manifesto. Anne Dacier had published (1699) a translation of the Iliad, and La Motte, who knew no Greek, made a translation (1714) in verse founded on her work.
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